A sick and desperate John travels to Mexico for a risky and experimental medical procedure in hopes of a miracle cure for his cancer only to discover the entire operation is a scam to defraud the most vulnerable.

Jigsaw abducts a doctor in order to keep himself alive while he watches his new apprentice put an unlucky citizen named Jeff through a brutal test.

A young Japanese woman who holds the key to stopping the evil spirit of Kayako, travels to the haunted Chicago apartment from the sequel, to stop the curse of Kayako once and for all.